Glucose metabolism in small subcortical structures in Parkinson's disease
Identifieur interne : 001521 ( Main/Exploration ); précédent : 001520; suivant : 001522Glucose metabolism in small subcortical structures in Parkinson's disease
Auteurs : Per Borghammer [Danemark] ; S Ren B. Hansen [Danemark] ; Carsten Eggers [Allemagne] ; Mallar Chakravarty [Canada] ; KIM VANG [Danemark] ; Joel Aanerud [Danemark] ; Rüdiger Hilker [Allemagne] ; Wolf-Dieter Heiss [Allemagne] ; Anders Rodell [Danemark] ; Ole L. Munk [Danemark] ; David Keator [États-Unis] ; Albert Gjedde [Danemark]Source :
- Acta neurologica scandinavica [ 0001-6314 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Glucose.
English descriptors
- KwdEn :
Abstract
Objectives - Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei. Materials and metlaods - Using the HRRT, we performed [18F]-fluorodeoxyglucose (FDG) scans on 21 patients with PD and 11 age-matched controls. We employed three types of normalization: white matter, global mean, and data-driven normalization. We performed volume-of-interest analyses of small subcortical gray matter structures. Voxel-based comparisons were performed to investigate the extent of cortical hypometabolism. Results - The most significant level of relative subcortical hypermetabolism was detected in the external pallidum (GPe), irrespective of normalization strategy. Hypermetabolism was suggested also in the internal pallidum, thalamic subnuclei, and the putamen. Widespread cortical hypometabolism was seen in a pattern very similar to previously reported patterns in patients with PD. Conclusion - The presence and extent of subcortical hypermetabolism in PD is dependent on type of normalization. However, the present findings suggest that PD, in addition to widespread cortical hypometabolism, is probably characterized by true hypermetabolism in the GPe. This finding was predicted by the animal 2-deoxyglucose autoradiography literature, in which high-magnitude hypermetabolism was also most robustly detected in the GPe.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Glucose metabolism in small subcortical structures in Parkinson's disease</title><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Hansen, S Ren B" sort="Hansen, S Ren B" uniqKey="Hansen S" first="S Ren B." last="Hansen">S Ren B. Hansen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Eggers, Carsten" sort="Eggers, Carsten" uniqKey="Eggers C" first="Carsten" last="Eggers">Carsten Eggers</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University of Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Chakravarty, Mallar" sort="Chakravarty, Mallar" uniqKey="Chakravarty M" first="Mallar" last="Chakravarty">Mallar Chakravarty</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Rotman Research Institute, Baycrest Hospital and Mouse Imaging Center, Hospital for Sick Children</s1><s2>Toronto, ON</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, ON</wicri:noRegion></affiliation></author><author><name sortKey="Kim Vang" sort="Kim Vang" uniqKey="Kim Vang" last="Kim Vang">KIM VANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Aanerud, Joel" sort="Aanerud, Joel" uniqKey="Aanerud J" first="Joel" last="Aanerud">Joel Aanerud</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University of Frankfurt</s1><s2>Frankfurt</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Max-Planck Institute for Neurological Research</s1><s2>Cologne</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Max-Planck Institute for Neurological Research</wicri:noRegion><wicri:noRegion>Max-Planck Institute for Neurological Research</wicri:noRegion></affiliation></author><author><name sortKey="Rodell, Anders" sort="Rodell, Anders" uniqKey="Rodell A" first="Anders" last="Rodell">Anders Rodell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Munk, Ole L" sort="Munk, Ole L" uniqKey="Munk O" first="Ole L." last="Munk">Ole L. Munk</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Keator, David" sort="Keator, David" uniqKey="Keator D" first="David" last="Keator">David Keator</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Brain Imaging Center, University of California</s1><s2>Irvine, CA</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine, CA</wicri:noRegion></affiliation></author><author><name sortKey="Gjedde, Albert" sort="Gjedde, Albert" uniqKey="Gjedde A" first="Albert" last="Gjedde">Albert Gjedde</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neuroscience and Pharmacology, University of Copenhagen</s1><s3>DNK</s3><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Department of Neuroscience and Pharmacology, University of Copenhagen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0181360</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0181360 INIST</idno><idno type="RBID">Pascal:12-0181360</idno><idno type="wicri:Area/PascalFrancis/Corpus">000208</idno><idno type="wicri:Area/PascalFrancis/Curation">000A44</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000159</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000159</idno><idno type="wicri:doubleKey">0001-6314:2012:Borghammer P:glucose:metabolism:in</idno><idno type="wicri:Area/Main/Merge">001573</idno><idno type="wicri:Area/Main/Curation">001521</idno><idno type="wicri:Area/Main/Exploration">001521</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Glucose metabolism in small subcortical structures in Parkinson's disease</title><author><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Nuclear Medicine, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Hansen, S Ren B" sort="Hansen, S Ren B" uniqKey="Hansen S" first="S Ren B." last="Hansen">S Ren B. Hansen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Eggers, Carsten" sort="Eggers, Carsten" uniqKey="Eggers C" first="Carsten" last="Eggers">Carsten Eggers</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University of Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Chakravarty, Mallar" sort="Chakravarty, Mallar" uniqKey="Chakravarty M" first="Mallar" last="Chakravarty">Mallar Chakravarty</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Rotman Research Institute, Baycrest Hospital and Mouse Imaging Center, Hospital for Sick Children</s1><s2>Toronto, ON</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, ON</wicri:noRegion></affiliation></author><author><name sortKey="Kim Vang" sort="Kim Vang" uniqKey="Kim Vang" last="Kim Vang">KIM VANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Aanerud, Joel" sort="Aanerud, Joel" uniqKey="Aanerud J" first="Joel" last="Aanerud">Joel Aanerud</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University of Frankfurt</s1><s2>Frankfurt</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Max-Planck Institute for Neurological Research</s1><s2>Cologne</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Max-Planck Institute for Neurological Research</wicri:noRegion><wicri:noRegion>Max-Planck Institute for Neurological Research</wicri:noRegion></affiliation></author><author><name sortKey="Rodell, Anders" sort="Rodell, Anders" uniqKey="Rodell A" first="Anders" last="Rodell">Anders Rodell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Munk, Ole L" sort="Munk, Ole L" uniqKey="Munk O" first="Ole L." last="Munk">Ole L. Munk</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Keator, David" sort="Keator, David" uniqKey="Keator D" first="David" last="Keator">David Keator</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Brain Imaging Center, University of California</s1><s2>Irvine, CA</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine, CA</wicri:noRegion></affiliation></author><author><name sortKey="Gjedde, Albert" sort="Gjedde, Albert" uniqKey="Gjedde A" first="Albert" last="Gjedde">Albert Gjedde</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>PET Centre, Aarhus University Hospitals</s1><s2>Aarhus</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neuroscience and Pharmacology, University of Copenhagen</s1><s3>DNK</s3><sZ>12 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Department of Neuroscience and Pharmacology, University of Copenhagen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Acta neurologica scandinavica</title><title level="j" type="abbreviated">Acta neurol. scand.</title><idno type="ISSN">0001-6314</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Acta neurologica scandinavica</title><title level="j" type="abbreviated">Acta neurol. scand.</title><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term><term>Glucose</term><term>Metabolism</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term><term>Subcortex</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Glucose</term><term>Métabolisme</term><term>Souscortex</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Glucose</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives - Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei. Materials and metlaods - Using the HRRT, we performed [<sup>18</sup>F]-fluorodeoxyglucose (FDG) scans on 21 patients with PD and 11 age-matched controls. We employed three types of normalization: white matter, global mean, and data-driven normalization. We performed volume-of-interest analyses of small subcortical gray matter structures. Voxel-based comparisons were performed to investigate the extent of cortical hypometabolism. Results - The most significant level of relative subcortical hypermetabolism was detected in the external pallidum (GPe), irrespective of normalization strategy. Hypermetabolism was suggested also in the internal pallidum, thalamic subnuclei, and the putamen. Widespread cortical hypometabolism was seen in a pattern very similar to previously reported patterns in patients with PD. Conclusion - The presence and extent of subcortical hypermetabolism in PD is dependent on type of normalization. However, the present findings suggest that PD, in addition to widespread cortical hypometabolism, is probably characterized by true hypermetabolism in the GPe. This finding was predicted by the animal 2-deoxyglucose autoradiography literature, in which high-magnitude hypermetabolism was also most robustly detected in the GPe.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Danemark</li><li>États-Unis</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Danemark"><noRegion><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name></noRegion><name sortKey="Aanerud, Joel" sort="Aanerud, Joel" uniqKey="Aanerud J" first="Joel" last="Aanerud">Joel Aanerud</name><name sortKey="Borghammer, Per" sort="Borghammer, Per" uniqKey="Borghammer P" first="Per" last="Borghammer">Per Borghammer</name><name sortKey="Gjedde, Albert" sort="Gjedde, Albert" uniqKey="Gjedde A" first="Albert" last="Gjedde">Albert Gjedde</name><name sortKey="Gjedde, Albert" sort="Gjedde, Albert" uniqKey="Gjedde A" first="Albert" last="Gjedde">Albert Gjedde</name><name sortKey="Hansen, S Ren B" sort="Hansen, S Ren B" uniqKey="Hansen S" first="S Ren B." last="Hansen">S Ren B. Hansen</name><name sortKey="Kim Vang" sort="Kim Vang" uniqKey="Kim Vang" last="Kim Vang">KIM VANG</name><name sortKey="Munk, Ole L" sort="Munk, Ole L" uniqKey="Munk O" first="Ole L." last="Munk">Ole L. Munk</name><name sortKey="Rodell, Anders" sort="Rodell, Anders" uniqKey="Rodell A" first="Anders" last="Rodell">Anders Rodell</name></country><country name="Allemagne"><noRegion><name sortKey="Eggers, Carsten" sort="Eggers, Carsten" uniqKey="Eggers C" first="Carsten" last="Eggers">Carsten Eggers</name></noRegion><name sortKey="Heiss, Wolf Dieter" sort="Heiss, Wolf Dieter" uniqKey="Heiss W" first="Wolf-Dieter" last="Heiss">Wolf-Dieter Heiss</name><name sortKey="Hilker, Rudiger" sort="Hilker, Rudiger" uniqKey="Hilker R" first="Rüdiger" last="Hilker">Rüdiger Hilker</name></country><country name="Canada"><noRegion><name sortKey="Chakravarty, Mallar" sort="Chakravarty, Mallar" uniqKey="Chakravarty M" first="Mallar" last="Chakravarty">Mallar Chakravarty</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Keator, David" sort="Keator, David" uniqKey="Keator D" first="David" last="Keator">David Keator</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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